In 2015, 17.5 million cancer cases were reported worldwide-a 33 percent increase from 2005. For most cancers, early diagnosis is key to improving survival rates. Radiology and histopathological images have long been the cornerstones in cancer detection and staging. Given the growing number of cancer cases, radiologists and pathologists need to analyze high volumes of imaging data.
Disease heterogeneity and interpatient variability contribute to differences in drug efficacy and safety. This variability initiates a cycle of trial and error that continues until a suitably safe and effective drug is identified for each individual patient. Personalized medicine promises to eliminate the trial-and-error method by incorporating predictive biomarkers into therapeutic decision making.
When it comes to sepsis, time is of the essence. Research has shown that for each hour that antibiotic administration to sepsis patients is delayed, there is a linear increase in the risk of mortality. Approximately 1.7 million individuals in the US develop sepsis each year, yet no gold standard exists for the diagnosis of sepsis in a clinical setting.
Approved in the US in 1954, warfarin is one of the most widely used oral anti-coagulants today. By inhibiting vitamin K-dependent activation of clotting factors, it prevents and treats thromboembolism associated with atrial fibrillation, artificial heart valves, and myocardial infarction. Dosing challenges Despite being used for more than 60 years, warfarin therapy is beset with challenges.
Victoria M. Pratt, PhD, FACMG, is associate professor and director of Pharmacogenetics and Molecular Genetics Laboratories at Indiana University School of Medicine. She graduated with a Ph.D. in medical and molecular genetics from Indiana University School of Medicine in 1994. Prior to joining Indiana University, she was chief director, molecular genetics, for Quest Diagnostics Nichols Institute.
The Drug-Free Workplace Act, passed in the U.S. in 1988, prohibits federal employees, contractors, and grantees as well as those in federally-regulated industries or safety and security-related industries from possessing or using controlled substances. Although not mandated, several private employers have also adopted a drug-free workplace policy.
A scientist by training and a writer by choice, I am fascinated by brains! My PhD and postdoctoral research focused on identifying novel treatments for brain injury using compounds naturally found within the body. This blog is an effort to step back from the lab bench and answer the single most important question about scientific discoveries: why should anyone care?
"I hated the movie but decided to suffer through it because I had paid for the ticket...in 3D!" "The store was overpriced but I bought the dress because I drove all the way out there." "His business isn't doing well but he's sticking with it because he's invested so much time and money in it already!"
JoAnn Taylor remembers the texture of the pillow and the weight of it in her hands as she pressed it down on a 65 year-old widow's face, snuffing out her life. She confessed to the murder in 1989, recounting the incident in great detail.
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