Brittany Enzmann

Scientific Marketing Professional

United States

I am a scientific marketing professional with over a decade of research experience who creates and manages content for the biotech and life science industries. I am passionate about leveraging my scientific and creative skills to communicate compelling messages while maintaining scientific integrity. I enjoy creating a variety of materials for inbound and outbound marketing, technical/product support, and sales enablement. It is an exciting time to be in the life sciences, and I look forward to communicating about the new innovations to come.

Contact me at: [email protected]


Scientific Marketing

CRISPR Screening 101

Functional genetic screens are a powerful tool for understanding the genetic underpinnings of biological pathways at a systems level. Through the induction of hundreds to thousands of genome-wide modulations, these screens enable researchers to form hypotheses about genetic associations with normal or disease phenotypes. Causal relationships between the genes and phenotypes are then validated through further screening and experimentation.

CRISPR Knockout Cell Lines | Fastest Path to Becoming a Genome Engineer

High CRISPR knockout efficiencies (80-90% KO frequency) can be quickly and inexpensively generated in a heterogeneous population of cells, referred to as a Knockout Cell Pool. This has enabled more researchers to take advantage of genome engineering in their research without needing to optimize CRISPR protocols.

Gene Drives Explained: How to Solve Problems with CRISPR

Gene drives are self-propagating mechanisms by which desired genetic variants can be spread through a population faster than traditional Mendelian inheritance. CRISPR is making this strategy so effective that alleles can continue their spread if they confer disadvantageous traits, such as sterility, to an organism.

Overcoming Barriers of Gene Editing in iPS Cells

One of the most widely-used applications of iPS cells is disease modeling. Using the powerful gene-editing tool, CRISPR, researchers can introduce specific mutations to healthy cells to recapitulate diseases. Alternatively, one can revert the genotype of cells taken from individuals with a disease to wild type.

The Problems of Using Plasmids for CRISPR Genome Editing

Several researchers use plasmid transfection for their CRISPR genome editing experiments, but is that the best strategy? High off-target effects, variable editing efficiencies, and integration in host genome are just a few of the reasons why RNPs have quickly become the more efficient alternative to plasmids.

Tips & Tricks
Protein Analysis of Knockouts

CRISPR is a powerful molecular tool that can be used to make a number of different genomic modifications. One of the most common uses of CRISPR is to knock out a gene of interest so that no functional protein is produced. This technique is often used to elucidate the role that genes and their products play in biological processes and disease pathways.

Tech Note
Precision CRISPR Editing of Induced Pluripotent Stem (iPS) Cells

A significant amount of biomedical research relies on the use of immortalized cell lines, which are easy to use and manipulate. However, these cell lines are often genetically abnormal and may not faithfully recapitulate the characteristics of the tissue they are intended to represent. Takahashi and Yamanaka’s 2006 work on induced pluripotent stem (iPS) cells was a seminal innovation in the biomedical field.

CRISPR Journal

CRISPR is an immensely powerful research tool that has revolutionized the way scientists manipulate genomes. In particular, CRISPR-mediated gene knockouts play key roles in drug discovery, understanding gene function, and other uses that improve the world around us.

How CRISPR Is Accelerating Drug Discovery

The drug discovery process, in which compounds are screened and evaluated for therapeutic use, has resulted in safe and effective therapies for a variety of diseases. However, assessments of new compounds for drug development are notoriously long and costly; they typically span more than a decade and exceed a billion dollars.

CRISPR 101: A Complete Guide to CRISPR Knockouts

Genome editing involves the deletion, insertion, or modification of specific DNA sequences in the genome. For many years, researchers had been trying to develop easy and cost-effective genome editing tools to address problems across a wide spectrum of fields. For instance, gene therapy in humans could progress rapidly if one could simply eliminate the gene responsible for a certain genetic disorder.