A love for pathology, informatics, and AI coupled with an inextinguishable drive to illustrate the multi-dimensional landscape of medicine today so that these blueprints may serve to navigate the world of tomorrow.
Volume 8, Issue 1, Pages 145–161 https://doi.org/10.1093/jalm/jfac119
Machine learning has been leveraged for image analysis applications throughout a multitude of subspecialties. This position paper provides a perspecti...
Volume 15, Issue 4, Pages 759-785. https://doi.org/10.1016/j.path.2022.08.001
Digital pathology (DP) has disrupted the practice of traditional pathology, including applications in education, research, and clinical practice. Contemporary whole slide imaging (WSI) devices include technological advances that help address some of the challenges facing modern pathology, such as in ...
Diagnostic devices, methodological approaches, and traditional constructs of clinical pathology practice, cultivated throughout centuries, have transformed radically in the wake of explosive technological growth and other, e.g., environmental, catalysts of change.
Patel, Ankush U. MD; Patel, Uresh S. MD; May, Eugene F. MD Editor(s): Avery, Robert DO; Golnik, Karl C. MD; Froment, Caroline MD, PhD; Wang, An-Guor MD Author Information Department of Laboratory Medicine and Pathology (AUP), Mayo Clinic, Rochester, Minnesota; Department of Radiology (USP), Swedish Medical Center, Seattle, Washington; and Departments of Ophthalmology and Neurology (EFM), University of Washington, Seattle, Washington.
Digital workflow transformation continues to sweep throughout a diversity of pathology departments spanning the globe following catalyzation of whole slide imaging (WSI) adoption by the SARS-CoV-2 (COVID-19) pandemic. The utility of WSI for a litany of use cases including primary diagnosis has been emphasized during this period, with WSI scanning devices gaining the approval of healthcare regulatory bodies and practitioners alike for clinical applications following extensive validatory efforts.
Anastomosing hemangioma (AH), a rare benign genitourinary tract hemangioma is subject to frequent misdiagnosis due to its rarity and clinical, histological, and immunohistochemical similarities it shares with several diagnoses, including well-differentiated angiosarcoma (AS). This is particularly true of angiosarcoma, nearly identical to AH when presented in tissue samples of limited size.
Case presentation A 37-year-old male presenting to The Ohio State University for evaluation of a three-year duration of intermittent, painless, gross hematuria accompanied by initial episodes of hematospermia prompted a CT urogram investigation indicating a 7.2 cm lobulated ill-defined mass arising from the seminal vesicles.
Brain necrosis resulting from therapeutic irradiation to the whole brain, partial brain or stereotactic radiosurgery (SRS) is commonly referred to as radionecrosis (RN). RN is an infrequent yet well recognized SRS treatment risk for malignant, metastatic and certain benign tumors such as AVM's.
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Psychedelic effects and their impact on mental health symptoms have been well documented in medical literature. However, a more tangible understanding of the different subtypes of the psychedelic experience and their direct relationship to specific therapeutic outcomes remains missing.
Mescaline may be beneficial in the treatment of alcoholism and mental health disorders, according to researchers from Neural Therapeutics Inc. in a recent publication featured in the medical journal Neuropharmacology. Highlights of the study include: Mescaline appears safe for consumption, with intoxication typically mild and easily treatable.
Healthcare practitioner beliefs and attitudes concerning psilocybin-assisted therapy (PAT) primarily influence their willingness to offer PAT as a treatment option for eligible patients, according to researchers from the University of Texas Health Science Center's McGovern Medical School.
Brazilian researchers reviewed a series of published studies to draw further insight into the effects of combined ketamine and alcohol use. Findings were analyzed in conjunction with known molecular interactions of ketamine and alcohol throughout the body to conclude that when used in combination, the substances held the potential to negatively impact a number of organs including the liver, gallbladder, heart, and kidneys, while also increasing the risk for adverse behavioral and mental...
Researchers at the Department of Medical Ethics and Health Policy (Perelman School of Medicine, University of Pennsylvania), argued for the development and adoption of a standardized, objective, and medically-founded vocabulary for psychedelics for use by researchers, clinicians, and patient-centric organizations including commercial enterprises. Different language choices were offered to compel thinking from those within the clinical sphere.
Brain-wave patterns and psychological effects that have been observed in humans after taking high doses of psychedelics have been reported from those taking low doses of LSD, raising the possibility that very low doses of LSD may produce therapeutic effects that do not invoke, or are dependent upon, the full psychedelic experience.
Ketamine may improve the quality of recovery (QoR) in patients undergoing thoracoscopic, i.e., chest, surgery when given around the time of procedure (perioperatively). Recently published results from a clinical trial conducted at a university hospital suggest that perioperative administration of "S"-ketamine enhanced the quality of recovery in patients who underwent video-assisted thoracic surgery (VATS), including improvements in depression and pain levels experienced after surgery.
The medical use of psilocybin, the main psychoactive component of psilocybin-producing ("magic") mushrooms, has been explored in a litany of disease states, as recently reported in a comprehensive review evaluating the medical application of psilocybin in a smattering of conditions related to neuropsychiatry.
A recent clinical study explored the use of psilocybin therapy as an adjunct to psychotherapy in patients with treatment-resistant depression. Most study participants demonstrated a clinically significant response to psilocybin therapy, with over 50% of patients exhibiting remission from major depressive disorder (MDD). More than 264 million individuals of all ages are affected with MDD worldwide.